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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Mikus D., Sikiric P., Seiwerth S., Petricevic A., Aralica G., Druzijancic N., Rucman R., Petek M., Pigac B., Perovic D., et al

That extended duration is what makes weekly dosing possible, but it also means the body is exposed to sustained amylin receptor activation far beyond what natural physiology produces