Upon binding to the tyrosine kinase B receptor (TrkB), BDNF triggers downstream signaling pathways such as mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) and PI3K/Akt, governing neuronal proliferation and differentiation ( As one of the important free bile acids present in BC, HDCA can effectively protect NVU in NVU ODG/R
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