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A 2010 study also found kidney function declined much quicker in one form of kidney disease in those who supplemented B12 compared to no supplementation.[2] It is difficult to 100% confirm all forms used in these studies were cyanocobalamin, but the ones that did mention the type of B12, did use cyanocobalamin and this is often the most commonly supplemented form

For severe cases, the first dose is usually 1,000 mcg given intramuscularly every day or every other day for a week or two

Bone marrow test

Those with any condition listed above, or those who would simply like additional cobalamin, should buy vitamin B12 injections due to this method bypassing potential barriers to absorption and goes right into the bloodstream

Different second mechanism, different molecular design, not interchangeable