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Distribution of interstitial cells of Cajal and nitrergic neurons in normal and diabetic human appendix

The NRF2 protein isoforms encoded by these splice variants lack the KEAP1 interaction domain, thus preventing NRF2 degradation and resulting in protein stabilization and transcription of NRF2 target genes [183]

All investigations were performed after approval by the Ethical Committee of the University of Lodz (decision identification code: 9/KBBN-U/II/2017, approved on 6 November 2017)

Overt vitamin B6 deficiency is rare, but approximately 10 percent of Americans may have inadequate B6 status, and it often occurs with deficiencies in other B vitamins like folate and B12

In CVDs, oxidative stress drives endothelial dysfunction and cardiac remodeling [10, 11], while in cognitive impairment, it promotes AD hallmarks like amyloid- aggregation and tau hyperphosphorylation