Some never see meaningful results
The stable gastric pentadecapeptide BPC 157, an original cytoprotective antiulcer peptide that is used in ulcerative colitis and recently in a multiple sclerosis trial and that has an LD1 that has not been achieved [1,2,3,4,5,6,7,8,9,10,11], is known to have pleiotropic beneficial effects [1,2,3,4,5,6,7,8,9,10,11] and to interact with several molecular pathways [2, 27,28,29,30,31,32]
and IL-6, mitigating the chronic low-grade inflammation (inflammaging) that contributes to tissue breakdown and cellular senescence
-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway
Our study suggests that the increased expression and nuclear distribution of p53-pS15 in keloids are associated with the promotion of pro-senescence regulation causing the cell cycle arrest and resistance to apoptosis