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In addition to stimulating the increase of eosinophils, neutrophils, mast cells, and macrophages (red box), CS can also combine with RAGE to further stimulate the expression of IL-33, gradually aggravating airway remodeling

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Specify smoke type such as cigarette, cigar, vape, or hookah, along with color, density, direction, and lighting

Disturbance in proliferation together with weakened migration can lead to decreased availability of MSCs in the healing tissue, which could potentiate the detrimental effect of smoking in vivo

And I am just one single person in a sea of smokers worldwide