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Furthermore, cotreatment of the LArginine + Tirzepatide group for 27 days resulted in a significant elevation of pAkt expression in the pancreatic acinar cells compared to the LArginine group at the same time point (Figure 7C,D)

This makes the mechanisms complementary rather than redundant

Additionally, FSP1 inhibitors, as novel non-GPX4-dependent targeted agents, have demonstrated potential to overcome drug resistance in prospective studies of breast cancer and non-small cell lung cancer (131)

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