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This should be taken into account in the small number of affected individuals with PWS and growth failure who exhibit normal growth hormone responses after standard stimulation tests (109)

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DSIP in humans can thus sustain natural sleep functions, and is well tolerated, with no obvious side effects observed

The creation of microthrombi inside the microcirculation can also hinder blood flow, while increasing blood viscosity (thickness) can impede blood flow via these smaller capillaries (Miranda et al., 2016)