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FIGURE 2 The role of oxidative stress in articular cartilage degeneration Biochemical analysis of degenerative cartilage from patients with OA showed that there was a pathological relationship between the downregulation of SOD2 and cartilage degeneration in the progression of OA, suggesting that the redox balance centred on SOD2 in mitochondria plays a central role in the pathogenesis of KOA (Ruiz-Romero et al., 2009

10.1186/1471-2202-13-33 [DOI] [PMC free article] [PubMed] [Google Scholar] Ishy P., Fagerlund B., Broberg B., Bak N., Knop F., Glenthj B., et al

Acknowledgement The Gill Fellowship, a George Washington University program that provides support to first-year medical students conducting research under the guidance of faculty in the School of Medicine and Health Sciences, supported this work

It also plays a key role in healing and enzymatic function, especially in cellular defense mechanisms against oxidative stress

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