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Selective CBS inhibitors with minimal off-target effects on other PLP-dependent enzymes, CPERS-specific CARS modulators, and highly selective ETHE1 and TST inhibitors have not yet been reported
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The compound is currently in Phase 3 clinical trials and is not yet approved by the FDA or Health Canada
Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death
The authors point out that doxycycline-associated skin hyperpigmentation seems to be uncommon and they summarize 18 patients in the literature with this side effect
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