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At the primary 32-week endpoint, 82.0% of participants on 6 mg achieved at least 5% weight loss compared to 10.5% with placebo

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While roGFP2 WT was completely oxidized at even very low PfGrx C32S/C88S (SSG) concentrations, 1 M PfGrx C32S/C88S (SSG) glutathionylated approximately 50% of 1 M roGFP2 C151S (SH) suggesting that the redox couples roGFP2 C151S (SSG)/roGFP2 C151S (SH) and PfGrx C32S/C88S (SSG)/PfGrx C32S/C88S (SH) have very similar redox potentials