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This systematic review and meta-analysis aimed to assess the impact of GLP-1 RA use on bowel preparation during lower GI endoscopy, focusing on clinical outcomes and procedure-related safety

It is located near the electron transport chain, where ROS are generated, lacks protective histones, and has more limited repair mechanisms

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It must be emphasized that Level C evidence mainly supports the high-frequency occurrence of common endpoints, but is not enough to prove the necessity or direction of barrier repair in the causal chain