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To tackle this issue, we started by examining the physiology of BDNF-TrkB signalling in iSPNs, the most vulnerable neurons in HD

Using a monoclonal antibody capable of detecting acridine on PR-RBCs, researchers found that 3% (5/159) patients in the PR-RBC arm had developed low titer IgG antibodies to acridine 28 to 80 days post-surgery