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These medications work by mimicking naturally occurring hormones that stimulate insulin secretion in response to food intake, suppress glucagon release, slow gastric emptying, and promote satiety through central nervous system pathways

These actions lead to reduced appetite and gradual weight loss

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BMC Medicine , 21(1), pp.120

How to continue losing weight on semaglutide While there isnt a set time limit after which semaglutide automatically becomes less effective, your bodys response to the drug depends on the rest of your lifestyle, particularly diet, exercise and underlying conditions, explains Jamie Rutland, MD, BuzzRx Medical Advisor