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Safety Considerations, Contraindications, and Who Should Seek Provider Guidance Patients with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN2) should not use GLP-1 agonists due to animal-model data linking these agents to C-cell proliferation

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N Engl J Med 2013;369:13271335

We next optimized a NRF2 transcriptional signature resulting in a set of 59 genes based on their contribution to the model and overlap with previously reported NRF2 signatures (Figs