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This combination of requirements makes NMDAR a coincidence detector for coordinated presynaptic activity that supplies glutamate and postsynaptic activation that depolarizes the dendrite

On the other hand, the contribution of GLP-1R to BAT activation is likely secondary to G49 actions in the central nervous system (CNS) (i.e., Th mRNA) where GLP-1Rs are highly expressed in the hypothalamus 54 and to the activation of GLP-1R-mediated pancreatic insulin secretion-driven de novo lipogenesis and the subsequent series of metabolic events discussed above

Glutamine-derived aspartate is required for eIF5A hypusination-mediated translation of HIF-1alpha to induce the polarization of tumor-associated macrophages

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