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Comparative studies indicate semaglutide producing a 15.8 percent mean weight loss at 68 weeks versus 6.4 percent with liraglutide, emphasizing its strong and sustained impact on weight management

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It also has a distinctive regulatory position: it was previously an FDA-approved product (marketed as Geref, a diagnostic agent) before being voluntarily withdrawn from the market, and that prior-approval history has given it a more stable standing for compounding than most other peptides