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From a biochemistry perspective it's actually the other way round, it's the folate that is doing the work and B12 is enabling that work in what's called the "folate" and "methionine" cycles

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Initially, it may cause purging, but acne should not worsen over time

Nonetheless, open cholecystectomy, involving a larger cut in the abdominal wall, may be necessary in some cases (Shaffer 2018