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Safety Profiles and Tolerability Considerations GI side effects like sickness, vomiting, and diarrhea are common with both peptides

Hepatol Commun

There are four main types of HH: Type 1 (sliding), the most common, is the herniation of the esophago-gastric junction (EGJ) above the diaphragm, leaving the stomach in the abdomen

Curr Pharm Des 20:11261135 Sikiri P, Petek M, Ruman R, Seiwerth S, Grabarevi Z, Rotkvi I, Turkovi B, Jagi V, Mildner B, Duvnjak M, Lang N, Danilovi Z, Cviko A, Kolega M, Sallmani A, Djai S, Bura M, Brki T, Bani M, Dodig M, Cori V, imievi V, Veljaca M, Erceg D, Jeek D, Simuni-Banek L, Skroza N, Buli K, Buljat G, Hanevaki M, Orihova V, Luinger D, Culig J, Separovi J, Marovi A, Mie S, Suchanek E, Matoz W, Perovi D, Gjurain M, Mikulandra S, Dernikovi K, Cuk V, Karakas I (1993) A new gastric juice peptide, BPC

FDA materials identify compounded injectable GHK-Cu as a safety concern because of potential immunogenicity, aggregation, peptide-related impurities, and limited human safety data 8