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The trial reported that the 109 subjects who chewed tobacco had 14% higher testosterone and 24% lower sperm count compared to the non-users

8.5 Geriatric Use A combined single- and multiple-dose pharmacokinetic study demonstrated that the pharmacokinetics of 1 mg varenicline given once daily or twice daily to 16 healthy elderly male and female smokers (aged 6575 years) for 7 consecutive days was similar to that of younger subjects