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The exact mechanism by which semaglutide benefits knee OA requires further study, but initial results show great promise: A mean change in knee pain, which was assessed using the WOMAC criteria for pain scoring , demonstrated a reduction of 41.7 points for semaglutide and a decrease of 27.5 points for a matching placebo

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Researchers from those studies suggest this may be linked to improved brain signaling and reduced oxidative stress

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