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So in theory, people who have low testosterone and take semaglutide experience more of a loss of muscle mass. Resistance training and a high-protein diet are essential for preserving musclewhether youre on TRT, semaglutide, or both, says Lee

Drug makers are also seeking alternative treatments for patients who struggle to remain on GLP-1s long term

And growth hormone is closely tied to: Collagen production Skin thickness Elasticity Muscle tone As we age, GH levels naturally decline