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The SURMOUNT-1 trial protocol allowed one dose de-escalation for intolerable side effects, which underscores that slower titration is acceptable and sometimes preferred

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They are further characterized by at least one daytime impairment, such as 1 : Physical and/or mental fatigue Sleepiness Cognitive problems Social, family, school, or workplace dysfunction Behavioral problems Low energy or motivation Tendency to make more errors or experience accidents Concern about or dissatisfaction with sleep A person who has experienced such sleep problems and daytime impairments at least three times per week for at least three months can be diagnosed with chronic insomnia, whereas less persistent insomnia is considered short-term

Homeostasis of the gut barrier and potential biomarkers