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Experimental Setup Mice were implanted with pancreatic tumor cells and split into four treatment groups: Vehicle control (no treatment) Low-dose Reta (1 nmol/kg, subcutaneously) Anti-PD-1 immunotherapy (10 mg/kg, intraperitoneally) Combination Reta + anti-PD-1 Treatments were given once every three days for two weeks after tumors were established

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