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These changes are accompanied by increased hippocampal levels of neurotransmitters and neurotrophic factorsincluding 5-HT, GABA, and brain-derived neurotrophic factor (BDNF)along with reduced inflammatory markers such as interleukin-6 (IL-6) (Cai et al., 2022)

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For instance, the development of inhibitors targeting DAMPs and pertinent nanomaterial-based drugs could prove instrumental [328]