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Valenzuela-Vallejo L, Guatibonza-Garcia V, Mantzoros CS

Neuropharmacology 186:108467

Finally, oral interventions such as orforglipron have demonstrated weight reduction of up to 11.2% at 72 weeks, offering a needle-free alternative for patients with metabolic disease who may prefer oral therapies

If youre losing weight too quickly without trying to, your clinician may slow the dose schedule

For instance, the gastrointestinal side effects commonly associated with Ozempicsuch as nausea, vomiting, and reduced appetitemay contribute to feelings of discomfort, fatigue, or irritability, which could manifest as mood changes